Long noncoding RNAs in hematopoiesis
نویسندگان
چکیده
منابع مشابه
Long noncoding RNAs in hematopoiesis
Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, a...
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Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes, including epigenetic control of transcription, mRNA stability, and protein lo...
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A remarkable discovery of whole-genome sequencing studies initiated at the turn of this century was that protein coding exons account for less than 2% of mammalian DNA. Subsequent largescale transcriptome studies have established that at least two-thirds of the genome is nonetheless transcribed into RNA, exposing novel and exciting layers of genetic regulation. Throughout eukaryotic evolution, ...
متن کاملLong noncoding RNAs in hematopoiesis [version 1; referees: 2 approved]
Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, a...
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Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncR...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2016
ISSN: 2046-1402
DOI: 10.12688/f1000research.8349.1